Preparation of 1-Substituted Tetrahydro-β-carbolines by Lithiation–Substitution
Author:
Affiliation:
1. Department of Chemistry, University of Sheffield, Sheffield S3 7HF, United Kingdom
2. AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom
Funder
University of Sheffield
AstraZeneca
Engineering and Physical Sciences Research Council
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.joc.5b00725
Reference37 articles.
1. aBeak, P.; Johnson, T. A.; Kim, D. D.; Lim, S. H.InOrganolithiums in Enantioselective Synthesis;Hodgson, D. M., Ed.Springer-Verlag:Berlin, 2003; p139.
2. bDegennaro, L.; Musio, B.; Luisi, R.InLithium Compounds in Organic Synthesis,Luisi, R., Capriati, V., Eds.Wiley-VCH:Weinheim, Germany, 2014; Ch. 7, p191.
3. Dynamic Thermodynamic and Dynamic Kinetic Resolution of 2-Lithiopyrrolidines
4. An Experimental and in Situ IR Spectroscopic Study of the Lithiation–Substitution of N-Boc-2-phenylpyrrolidine and -piperidine: Controlling the Formation of Quaternary Stereocenters
5. Synthesis of 2-Arylpiperidines by Palladium Couplings of Aryl Bromides with Organozinc Species Derived from Deprotonation of N-Boc-Piperidine
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