Exploration of a Nitromethane-Carbonylation Strategy during Route Design of an Atropisomeric KRASG12C Inhibitor-Reference-Cited by-同舟云学术

Exploration of a Nitromethane-Carbonylation Strategy during Route Design of an Atropisomeric KRASG12C Inhibitor

Published:2021-10-15 Issue: Volume: Page:
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Douglas James J.¹^ORCID,Tatton Matthew R.¹,de Bruin Daniël¹²,Buttar David¹,Cook Calum¹,Dai Kuangchu³,Ferrer Catalina⁴,Leslie Kevin⁵,Morrison James¹,Munday Rachel⁵,Ronson Thomas O.⁵^ORCID,Zhao Hucheng³

Affiliation:

1. Early Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca, Macclesfield SK10 2NA, U.K.

2. Organic Chemistry & Catalysis, Institution Debye Institute for Nanomaterials Science, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands

3. Changzhou SynTheAll Pharmaceutical Co. Ltd., No 589, North Yulong Road, Chunjiang Town, Xinbei District, Changzhou 213127, Jiangsu, PR China

4. Symeres, Kadijk 3, 9747 AT Groningen, The Netherlands

5. Chemical Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield SK10 2NA, U.K.

Funder

Universiteit Utrecht

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.1c01736

Reference30 articles.