Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C-Reference-Cited by-同舟云学术

Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C

Published:2020-02-05 Issue:9 Volume:63 Page:4468-4483
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kettle Jason G.¹^ORCID,Bagal Sharan K.¹,Bickerton Sue¹,Bodnarchuk Michael S.¹^ORCID,Breed Jason²,Carbajo Rodrigo J.¹,Cassar Doyle J.¹,Chakraborty Atanu¹,Cosulich Sabina¹,Cumming Iain¹,Davies Michael¹,Eatherton Andrew¹,Evans Laura¹,Feron Lyman¹,Fillery Shaun¹^ORCID,Gleave Emma S.²,Goldberg Frederick W.¹^ORCID,Harlfinger Stephanie¹,Hanson Lyndsey³,Howard Martin¹,Howells Rachel¹,Jackson Anne²,Kemmitt Paul¹,Kingston Jennifer K.¹,Lamont Scott¹,Lewis Hilary J.¹,Li Songlei⁴,Liu Libin⁴,Ogg Derek²,Phillips Christopher²,Polanski Radek²,Robb Graeme¹^ORCID,Robinson David¹,Ross Sarah¹,Smith James M.¹,Tonge Michael²,Whiteley Rebecca¹,Yang Junsheng⁴,Zhang Longfei⁴,Zhao Xiliang⁴

Affiliation:

1. Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.

2. Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K.

3. Oncology R&D, AstraZeneca, Alderley Park SK10 4TG, U.K.

4. Pharmaron Beijing Co., Ltd. 6 Taihe Road BDA, Beijing 100176 P. R. China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01720

Reference36 articles.