Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism
Author:
Affiliation:
1. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
2. Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
3. Wellspring Biosciences, La Jolla, CA, USA.
Abstract
Funder
National Institutes of Health
Memorial Sloan Kettering Cancer Center Experimental Therapeutics
LUNGevity Foundation Career Development Award
V Foundation
Publisher
American Association for the Advancement of Science (AAAS)
Subject
Multidisciplinary
Reference36 articles.
1. RAS oncogenes: weaving a tumorigenic web
2. Dragging Ras Back in the Ring
3. GEFs and GAPs: Critical Elements in the Control of Small G Proteins
4. Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene
5. T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes
Cited by 496 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Research progress on small molecule inhibitors targeting KRAS G12C with acrylamide structure and the strategies for solving KRAS inhibitor resistance;Bioorganic & Medicinal Chemistry;2024-02
2. Abnormalities in the KRAS Gene and Treatment Options for NSCLC Patients with the G12C Mutation in This Gene—A Literature Review and Single-Center Experience;Biomedicines;2024-01-31
3. Hedgehog signalling is involved in acquired resistance to KRASG12C inhibitors in lung cancer cells;Cell Death & Disease;2024-01-16
4. Drugging the undruggable: Advances in targeting KRAS signaling in solid tumors;International Review of Cell and Molecular Biology;2024
5. Revealing the mechanism of action of a first-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by 31P NMR;Journal of Biological Chemistry;2024-01
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3