A Local Desymmetrization Approach to Piperidinyl Acetic Acid γ-Secretase Modulators-Reference-Cited by-同舟云学术

A Local Desymmetrization Approach to Piperidinyl Acetic Acid γ-Secretase Modulators

Published:2021-10-12 Issue:21 Volume:86 Page:15481-15487
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Cheng Peng¹,Lu Haigen¹,Zu Liansuo¹^ORCID

Affiliation:

1. School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, Tsinghua University, Beijing 100084, China

Funder

Ministry of Science and Technology of the People's Republic of China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.1c01970

Reference14 articles.

1. Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead

2. Recent developments of small molecule γ-secretase modulators for Alzheimer's disease

3. aHannam, J. C.; Kulagowski, J. J.; Madin, A.; Ridgill, M. P.; Seward, E. Piperidines and related compounds for treatment of Alzheimer’s disease. WO2006/043064A1, 2006.

4. bGarcia, Y.; Hannam, J. C.; Harrison, T.; Hamblett, C. L.; Hubbs, J. L.; Kulagowski, J. J.; Madin, A.; Ridgill, M. P.; Seward, E. Piperidines and related compounds for the treatment of Alzheimer’s disease. US 8389547 B2, 2013.

5. Piperidine-derived γ-secretase modulators

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Multicomponent Mannich and Related Reactions;Reference Module in Chemistry, Molecular Sciences and Chemical Engineering;2024

2. Piperidine Derivatives: Recent Advances in Synthesis and Pharmacological Applications;International Journal of Molecular Sciences;2023-02-02

3. Local desymmetrization as an engine of stereochemical elaboration in total synthesis;Tetrahedron Letters;2022-05

4. A 2000 to 2020 Practitioner’s Guide to Chiral Amine Based Enantioselective Aldol Reactions:Common Ketone Substrates,Best Methods,in Water Reaction Environments,and Defining Nuances;European Journal of Organic Chemistry;2021-09