Recent developments of small molecule γ-secretase modulators for Alzheimer's disease-Reference-Cited by-同舟云学术

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Recent developments of small molecule γ-secretase modulators for Alzheimer's disease

Published:2020 Issue:9 Volume:11 Page:1003-1022
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Mekala Shekar¹²³⁴^ORCID,Nelson Grady¹²³⁴^ORCID,Li Yue-Ming¹²³⁴⁵^ORCID

Affiliation:

1. Chemical Biology Program

2. Memorial Sloan-Kettering Cancer Center

3. New York

4. USA

5. Pharmacology Graduate Program

Abstract

This review article highlights the recent progress and outlook for small molecule gamma secretase modulators for potential Alzheimer's therapies.

Funder

National Institute on Aging

National Cancer Institute

JPB Foundation

Cure Alzheimer's Fund

National Institute of Neurological Disorders and Stroke

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/MD/D0MD00196A

Reference95 articles.

1. Drug treatments in Alzheimer’s disease

2. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

3. Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

4. Alzheimer's Disease: The Amyloid Cascade Hypothesis

5. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

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1. Emerging paradigms in Alzheimer's therapy;European Journal of Pharmacology;2024-10

2. New precision medicine avenues to the prevention of Alzheimer’s disease from insights into the structure and function of γ-secretases;The EMBO Journal;2024-02-23

3. Targets, trials and tribulations in Alzheimer therapeutics;European Journal of Pharmacology;2024-01

4. Review on anti-alzheimer drug development: approaches, challenges and perspectives;RSC Advances;2024

5. Emerging Novel Therapeutic Approaches for the Treatment of Alzheimer’s Disease;Advances in Alzheimer's Disease;2024

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