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Piperidine-derived γ-secretase modulators

Published:2010-02 Issue:3 Volume:20 Page:1306-1311
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Hall Adrian,Elliott Richard L.,Giblin Gerard M.P.,Hussain Ishrut,Musgrave James,Naylor Alan,Sasse Rosemary,Smith Beverley

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference38 articles.

1. Cognitive Impairment: Dementia and Alzheimer's Disease

2. A Hundred Years of Alzheimer's Disease Research

3. Alzheimer’s disease pathogenesis and therapeutic interventions

4. The Pathogenesis of Senile Plaques

5. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB)

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1. A Local Desymmetrization Approach to Piperidinyl Acetic Acid γ-Secretase Modulators;The Journal of Organic Chemistry;2021-10-12

2. A 2000 to 2020 Practitioner’s Guide to Chiral Amine Based Enantioselective Aldol Reactions:Common Ketone Substrates,Best Methods,in Water Reaction Environments,and Defining Nuances;European Journal of Organic Chemistry;2021-09

3. Targeting Common Signaling Pathways for the Treatment of Stroke and Alzheimer’s: a Comprehensive Review;Neurotoxicity Research;2021-06-25

4. γ-Secretase inhibitors and modulators: Mechanistic insights into the function and regulation of γ-Secretase;Seminars in Cell & Developmental Biology;2020-09

5. Targeting Amyloidogenic Processing of APP in Alzheimer’s Disease;Frontiers in Molecular Neuroscience;2020-08-04

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