γ-Secretase inhibitors and modulators: Mechanistic insights into the function and regulation of γ-Secretase-Reference-Cited by-同舟云学术

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γ-Secretase inhibitors and modulators: Mechanistic insights into the function and regulation of γ-Secretase

Published:2020-09 Issue: Volume:105 Page:43-53
ISSN:1084-9521
Container-title:Seminars in Cell & Developmental Biology
language:en
Short-container-title:Seminars in Cell & Developmental Biology

Author:

Nie Pengju,Vartak Abhishek,Li Yue-Ming

Funder

NIH

JPB Foundation

MetLife Foundation

Cure Alzheimer’s Fund

Edward and Della L. Thome Memorial Foundation

Alzheimer's Research Trust

Publisher

Elsevier BV

Subject

Cell Biology,Developmental Biology

Reference108 articles.

1. Alzheimer’s disease: the amyloid cascade hypothesis;Hardy;Science,1992

2. The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics;Hardy;Science,2002

3. Amyloid precursor protein processing and Alzheimer’s disease;O’Brien;Annu. Rev. Neurosci.,2011

4. Development and mechanism of γ-Secretase modulators for alzheimer’s disease;Crump;Biochemistry,2013

5. Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans;Brown;Cell,2000

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1. γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS);The Lancet Neurology;2024-09

2. Generation and Characterization of a Novel Knockin Mouse Model Expressing PSEN1 D385A: Implications for Investigating Herbal Drug Effects in γ-Secretase Activity;Journal of Alzheimer's Disease;2024-07-30

3. Navigating the Maze of Alzheimer’s disease by exploring BACE1: Discovery, current scenario, and future prospects;Ageing Research Reviews;2024-07

4. NOTCH3 and Pulmonary Arterial Hypertension;International Journal of Molecular Sciences;2024-06-06

5. Neuronal γ-secretase regulates lipid metabolism, linking cholesterol to synaptic dysfunction in Alzheimer’s disease;Neuron;2023-10

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