Synthesis of Novel N-1 (Allyloxymethyl) Analogues of 6-Benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, Emivirine) with Improved Activity Against HIV-1 and Its Mutants-Reference-Cited by-同舟云学术

Synthesis of Novel N-1 (Allyloxymethyl) Analogues of 6-Benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, Emivirine) with Improved Activity Against HIV-1 and Its Mutants

Published:2002-11-23 Issue:26 Volume:45 Page:5721-5726
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

El-Brollosy Nasser R.¹,Jørgensen Per T.¹,Dahan Berit¹,Boel Anne Marie¹,Pedersen Erik B.¹,Nielsen Claus¹

Affiliation:

1. Nucleic Acid Center,§ Department of Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense M Denmark and Retrovirus Laboratory, Department of Virology, State Serum Institute, Artillerivej 5, DK-2300 Copenhagen, Denmark

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm020949r

Reference27 articles.

1. Molecular Targets for AIDS Therapy

2. Targets and strategies for the antiviral chemotherapy of AIDS

3. Non-Nucleoside Reverse Transcriptase Inhibitors: The NNRTI Boom

4. A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine

5. Synthesis and Antiviral Activity of 6-Benzyl Analogs of 1-[(2-Hydroxyethoxy)methyl]-5-(phenylthio)thymine (HEPT) as Potent and Selective Anti-HIV-1 Agents

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