Non-Nucleoside Reverse Transcriptase Inhibitors: The NNRTI Boom-Reference-Cited by-同舟云学术

Non-Nucleoside Reverse Transcriptase Inhibitors: The NNRTI Boom

Published:1999-12 Issue:6 Volume:10 Page:285-314
ISSN:2040-2066
Container-title:Antiviral Chemistry and Chemotherapy
language:en
Short-container-title:Antivir Chem Chemother

Author:

Pedersen Ole S¹,Pedersen Erik B¹

Affiliation:

1. Department of Chemistry, University of Southern Denmark, Odense University, DK-5230 Odense M, Denmark

Abstract

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are promising drugs for the treatment of HIV when used in combination with other anti-HIV drugs such as nucleoside reverse transcriptase (RT) inhibitors and protease inhibitors. The first generation of NNRTIs have, however, suffered from the rapid development of resistance. This review discusses the properties of the FDA-approved NNRTI drugs and focuses on the recent efforts being made to produce second generation inhibitors that circumvent this resistance problem.

Publisher

SAGE Publications

Link

http://journals.sagepub.com/doi/pdf/10.1177/095632029901000601

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