Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications-Reference-Cited by-同舟云学术

Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications

Published:2008-10-16 Issue:21 Volume:51 Page:7010-7014
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Li Jie Jack¹,Iula Donna M.¹,Nguyen Maria N.¹,Hu Lain-Yen¹,Dettling Danielle¹,Johnson Theodore R.¹,Du Daniel Y.¹,Shanmugasundaram Veerabahu¹,Van Camp Jennifer A.¹,Wang Zhi¹,Harter William G.¹,Yue Wen-Song¹,Boys Mark L.¹,Wade Kimberly J.¹,Drummond Elena M.¹,Samas Brian M.¹,Lefker Bruce A.¹,Hoge Garrett S.¹,Lovdahl Mark J.¹,Asbill Jeffrey¹,Carroll Matthew¹,Meade Mary Ann¹,Ciotti Susan M.¹,Krieger-Burke Theresa¹

Affiliation:

1. Departments of Chemistry, Dermatology Biology, Pharmaceutical Sciences, Pharmacokinetics and Drug Metabolism, and Drug Safety, Michigan Laboratories, Pfizer Global Research & Development, 2800 Plymouth Road, Ann Arbor, Michigan 48105

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm8009316

Reference26 articles.

1. Chemistry and Structural Biology of Androgen Receptor

2. Androgen Receptor Antagonists (Antiandrogens) Structure-Activity Relationships

3. Bicalutamide (Casodex®) in the treatment of prostate cancer

4. Treatment of androgenic disorders in women: acne, hirsutism, and alopecia

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