Phototoxicity─Medicinal Chemistry Strategies for Risk Mitigation in Drug Discovery

Author:

Harrison Tyler J.1ORCID,Chen Xin1ORCID,Yasoshima Kayo1,Bauer Daniel2ORCID

Affiliation:

1. Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, Massachusetts 02139, United States

2. Preclinical Safety, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference79 articles.

1. Sunlight and Vitamin D

2. Systematic review of light exposure impact on human circadian rhythm

3. Drug and chemical induced photosensitivity from a clinical perspective

4. International Council for Harmonization (ICH). Non-clinical safety studies for the conduct of human clinical trials for pharmaceuticals (ICH M3 R2), 2009; https://www.ich.org/page/multidisciplinary-guidelines.

5. International Council for Harmonization (ICH). Photosafety evaluation of pharmaceuticals (ICH S10), 2013; https://www.ich.org/page/safety-guidelines.

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