Discovery of (2<i>S</i>)-<i>N</i>-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-3-(6-(4-cyanophenyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-hydroxy-2-methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment-Reference-Cited by-同舟云学术

Discovery of (2S)-N-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-3-(6-(4-cyanophenyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-hydroxy-2-methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment

Published:2023-12-21 Issue:1 Volume:67 Page:322-348
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhang Wenqiang¹,Zhao Siqi²³,Luo Yi¹,Zhang Yan¹²³,Feng Yunrui¹,Tang Feng²³,Zhou Xiaoyu¹,Peng Shaoping²³,Fan Yawen¹,Xie Shaofei²³,Li Hongmei¹,Lai Qianlong¹,Fu Lingsheng¹,Luo Yi¹,Pei Sheng¹,Chen Zhuolin¹,Lu Tao¹⁴,Tang Renhong²⁵,Chen Yadong¹^ORCID,Jiao Yu¹^ORCID

Affiliation:

1. School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, P. R. China

2. State Key Laboratory of Neurology and Oncology Drug Development, Jiangsu Simcere Pharmaceutical Co., Ltd., 699-18 Xuan Wu Avenue, Nanjing 210042, P. R. China

3. Jiangsu Simcere Pharmaceutical Co., Ltd., 699-18 Xuan Wu Avenue, Nanjing 210042, P. R. China

4. State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, P. R. China

5. Simcere Zaiming Pharmaceutical Co., Ltd., 699-18 Xuan Wu Avenue, Nanjing 210042, P. R. China

Funder

China Pharmaceutical University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01417

Reference53 articles.

1. PATTERNED LOSS OF HAIR IN MAN: TYPES AND INCIDENCE

2. Prevalence of Male and Female Pattern Hair Loss in Maryborough

3. The hair cycle

4. Getting to the Core of the Dermal Papilla

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