Large Scale Synthetic Site Saturation GPCR Libraries Reveal Novel Mutations That Alter Glucose Signaling-Reference-Cited by-同舟云学术

Large Scale Synthetic Site Saturation GPCR Libraries Reveal Novel Mutations That Alter Glucose Signaling

Author:

Öling David¹^ORCID,Lawenius Lina¹,Shaw William²³,Clark Sonya⁴,Kettleborough Ross⁴,Ellis Tom²³^ORCID,Larsson Niklas¹,Wigglesworth Mark⁵

Affiliation:

1. Discovery Biology, Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D, 431 50 Mölndal, Sweden

2. Department of Bioengineering, Imperial College London, London SW7 2AZ, U.K.

3. Centre for Synthetic Biology, Imperial College London, London SW7 2AZ, U.K.

4. Twist Bioscience, San Francisco, California 94158, United States

5. Hit Identification, Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D, Macclesfield SK10 2NA, U.K.

Funder

AstraZeneca

Publisher

American Chemical Society (ACS)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Biomedical Engineering,General Medicine

Link

Reference22 articles.

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