1. Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 52a, A-6020 Innsbruck, Austria, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Strasse 65, D-88397 Biberach/Riss, Germany, CAMD Group, Institute of Pharmacy, University of Innsbruck, Innrain 52c, A-6020 Innsbruck, Austria, and Prestwick Chemicals, Inc., Boulevard Gonthier d’Andernach, Parc d’Innovation, 67400 Illkirch, France