Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53-Reference-Cited by-同舟云学术

Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

Published:2012-04-05 Issue:15 Volume:134 Page:6810-6818
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Wilcken Rainer¹²,Liu Xiangrui²,Zimmermann Markus O.¹,Rutherford Trevor J.²,Fersht Alan R.²,Joerger Andreas C.²,Boeckler Frank M.¹

Affiliation:

1. Laboratory for Molecular Design and Pharmaceutical Biophysics, Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard-Karls-University Tuebingen, Auf der Morgenstelle 8, 72076 Tuebingen, Germany

2. MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja301056a

Reference35 articles.

1. Halogen Bonding—A Novel Interaction for Rational Drug Design?

2. Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors

3. Halogen bonding: the σ-hole

4. Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells

5. 1,4-Benzodiazepine-2,5-diones as small molecule antagonists of the HDM2–p53 interaction: discovery and SAR

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