Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors-Reference-Cited by-同舟云学术

Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors

Published:2011-07-14 Issue:15 Volume:54 Page:5607-5611
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Xu Zhijian¹,Liu Zheng²,Chen Tong¹,Chen TianTian¹,Wang Zhen¹,Tian Guanghui¹,Shi Jing²,Wang Xuelan²,Lu Yunxiang³,Yan Xiuhua¹,Wang Guan¹,Jiang Hualiang¹,Chen Kaixian¹,Wang Shudong⁴,Xu Yechun¹,Shen Jingshan¹,Zhu Weiliang¹

Affiliation:

1. State key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China

2. Topharman Shanghai Co., Ltd., 1088 Chuansha Road, Shanghai 201209, China

3. Department of Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China

4. School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm200644r

Reference17 articles.

1. Halogen Bonding Based Recognition Processes: A World Parallel to Hydrogen Bonding

2. Halogen bonding: an electrostatically-driven highly directional noncovalent interaction