Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells-Reference-Cited by-同舟云学术

Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells

Published:2005-02-01 Issue:4 Volume:48 Page:909-912
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Grasberger Bruce L.¹,Lu Tianbao¹,Schubert Carsten¹,Parks Daniel J.¹,Carver Theodore E.¹,Koblish Holly K.¹,Cummings Maxwell D.¹,LaFrance Louis V.¹,Milkiewicz Karen L.¹,Calvo Raul R.¹,Maguire Diane¹,Lattanze Jennifer¹,Franks Carol F.¹,Zhao Shuyuan¹,Ramachandren Kannan¹,Bylebyl Gwendolyn R.¹,Zhang Marie¹,Manthey Carl L.¹,Petrella Eugene C.¹,Pantoliano Michael W.¹,Deckman Ingrid C.¹,Spurlino John C.¹,Maroney Anna C.¹,Tomczuk Bruce E.¹,Molloy Christopher J.¹,Bone Roger F.¹

Affiliation:

1. Johnson & Johnson Pharmaceutical Research & Development L.L.C., 665 Stockton Drive, Exton, Pennsylvania 19341

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm049137g

Reference24 articles.

1. p53, the Cellular Gatekeeper for Growth and Division

2. The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2

3. A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines 1 1Edited by A. R. Fersht