Exploring the Role of 2-Chloro-6-fluoro Substitution in 2-Alkylthio-6-benzyl-5-alkylpyrimidin-4(3H)-ones: Effects in HIV-1-Infected Cells and in HIV-1 Reverse Transcriptase Enzymes-Reference-Cited by-同舟云学术

Exploring the Role of 2-Chloro-6-fluoro Substitution in 2-Alkylthio-6-benzyl-5-alkylpyrimidin-4(3H)-ones: Effects in HIV-1-Infected Cells and in HIV-1 Reverse Transcriptase Enzymes

Published:2014-06-16 Issue:12 Volume:57 Page:5212-5225
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rotili Dante¹,Tarantino Domenico¹,Nawrozkij Maxim B.²,Babushkin Alexandre S.²,Botta Giorgia¹,Marrocco Biagina¹,Cirilli Roberto³,Menta Sergio¹,Badia Roger⁴,Crespan Emmanuele⁵,Ballante Flavio⁶⁷,Ragno Rino⁶,Esté José A.⁴,Maga Giovanni⁵,Mai Antonello¹⁸

Affiliation:

1. Dipartimento di Chimica e Tecnologie del Farmaco, Università degli Studi di Roma “La Sapienza”, P.le A. Moro 5, 00185 Roma, Italy

2. Volgograd State Technical University, pr. Lenina, 28, 400131 Volgograd, Russia

3. Dipartimento del Farmaco, Istituto Superiore di Sanità,, Viale Regina Elena 299, 00161 Rome, Italy

4. IrsiCaixa, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916 Badalona, Spain

5. Istituto di Genetica Molecolare IGM-CNR, via Abbiategrasso 207, 27100 Pavia, Italy

6. Rome Center for Molecular Design, Dipartimento di Chimica e Tecnologie del Farmaco, Università degli Studi di Roma “La Sapienza”, P.le A. Moro 5, 00185 Roma, Italy

7. Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis, School of Medicine, 700 South Euclid Avenue, St. Louis, Missouri 00185, United States

8. Istituto Pasteur—Fondazione Cenci Bolognetti, Università degli Studi di Roma “La Sapienza”, P.le A. Moro 5, 00185 Roma, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm500284x

Reference39 articles.

1. Selected non-nucleoside reverse transcriptase inhibitors (NNRTIs): The DABOs family

2. Dihydro-alkoxyl-benzyl-oxopyrimidine Derivatives (DABOs) As Non-Nucleoside Reverse Transcriptase Inhibitors: An Update Review (2001-2011)

3. 6-(Arylmethyl)pyrimidin-4(3H)-ones: anthology and prospects of highly efficient anti-HIV agents

4. New therapeutic landscape of NNRTIs for treatment of HIV: a look at recent data

5. Non-nucleoside reverse transcriptase inhibitors: a review on pharmacokinetics, pharmacodynamics, safety and tolerability

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