Evolution of the Bifunctional Lead μ Agonist/δ Antagonist Containing the 2′,6′-Dimethyl-l-tyrosine−1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (Dmt−Tic) Opioid Pharmacophore-Reference-Cited by-同舟云学术

Evolution of the Bifunctional Lead μ Agonist/δ Antagonist Containing the 2′,6′-Dimethyl-l-tyrosine−1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (Dmt−Tic) Opioid Pharmacophore

Published:2009-11-04 Issue:2 Volume:1 Page:155-164
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Balboni Gianfranco¹,Salvadori Severo²,Trapella Claudio²,Knapp Brian I.³,Bidlack Jean M.³,Lazarus Lawrence H.⁴,Peng Xuemei⁵,Neumeyer John L.⁵

Affiliation:

1. Department of Toxicology, University of Cagliari, I-09124, Cagliari, Italy

2. Department of Pharmaceutical Sciences and Biotechnology Center, University of Ferrara, I-44100 Ferrara, Italy

3. Department of Pharmacology and Physiology, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642

4. Medicinal Chemistry Group, Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North 6 Carolina 27709

5. Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, Massachusetts 02478

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/cn900025j

Reference39 articles.

1. Design of Multivalent Ligand Targeting G-Protein-Coupled Receptors

2. The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential

3. Simultaneous targeting of multiple opioid receptors: a strategy to improve side-effect profile

4. Evaluation of the Dmt−Tic Pharmacophore: Conversion of a Potent δ-Opioid Receptor Antagonist into a Potent δ Agonist and Ligands with Mixed Properties

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