Improved Stability of Proline-Derived Direct Thrombin Inhibitors through Hydroxyl to Heterocycle Replacement
Author:
Affiliation:
1. Departments of †Medicinal Chemistry, ‡Process Chemistry, §Drug Metabolism and Pharmacokinetics, ∥Preclinical Development, ⊥Pharmacology, and #Thrombosis, Merck Research Laboratories, Kenilworth, New Jersey 07033, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.5b00047
Reference10 articles.
1. Venous Thromboembolism
2. Prevalence of clinical venous thromboembolism in the USA: Current trends and future projections
3. Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor
4. Dabigatran Etexilate: A Review of Its Use in the Treatment of Acute Venous Thromboembolism and Prevention of Venous Thromboembolism Recurrence
5. The Metabolism and Disposition of the Oral Direct Thrombin Inhibitor, Dabigatran, in Humans
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