A Shift in Thinking: Cellular Thermal Shift Assay-Enabled Drug Discovery
Author:
Affiliation:
1. Pelago Bioscience AB, 17165 Solna, Sweden
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.2c00545
Reference32 articles.
1. Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
2. CETSA beyond Soluble Targets: a Broad Application to Multipass Transmembrane Proteins
3. Thermal proteome profiling monitors ligand interactions with cellular membrane proteins
4. From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9
5. A Tale of Two Tails: Efficient Profiling of Protein Degraders by Specific Functional and Target Engagement Readouts
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