From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9-Reference-Cited by-同舟云学术

From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9

Published:2020-01 Issue:1 Volume:27 Page:32-40.e3
ISSN:2451-9456
Container-title:Cell Chemical Biology
language:en
Short-container-title:Cell Chemical Biology

Author:

Petrilli Whitney L.,Adam Gregory C.,Erdmann Roman S.,Abeywickrema Pravien,Agnani Vijayalakshmi,Ai Xi,Baysarowich Jen,Byrne Noel,Caldwell John P.,Chang Wonsuk,DiNunzio Edward,Feng Zhe,Ford Rachael,Ha Sookhee,Huang Yongcheng,Hubbard Brian,Johnston Jennifer M.,Kavana Michael,Lisnock Jean-Marie,Liang Rui,Lu Jun,Lu Zhijian,Meng Juncai,Orth Peter,Palyha Oksana,Parthasarathy Gopal,Salowe Scott P.,Sharma Sujata,Shipman Jennifer,Soisson Stephen M.,Strack Alison M.,Youm Hyewon,Zhao Kake,Zink Deborah L.,Zokian Hratch,Addona George H.,Akinsanya Karen,Tata James R.,Xiong Yusheng,Imbriglio Jason E.

Funder

Merck & Co., Inc

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,Biochemistry

Reference40 articles.

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1. Identification of 4-amino-2-Pyridones as new potent PCSK9 inhibitors: From phenotypic hit discovery to in vivo tolerability;European Journal of Medicinal Chemistry;2024-02

2. Targeting Allosteric Site of PCSK9 Enzyme for the Identification of Small Molecule Inhibitors: An In Silico Drug Repurposing Study;Biomedicines;2024-01-26

3. Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): from bench to bedside;Signal Transduction and Targeted Therapy;2024-01-08

4. Identification of benzothiazoles as novel PCSK9 inhibitors;Bioorganic & Medicinal Chemistry Letters;2024-01

5. Targeted Degradation of PCSK9 In Vivo by Autophagy-Tethering Compounds;Journal of Medicinal Chemistry;2023-12-19