From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9

Author:

Petrilli Whitney L.,Adam Gregory C.,Erdmann Roman S.,Abeywickrema Pravien,Agnani Vijayalakshmi,Ai Xi,Baysarowich Jen,Byrne Noel,Caldwell John P.,Chang Wonsuk,DiNunzio Edward,Feng Zhe,Ford Rachael,Ha Sookhee,Huang Yongcheng,Hubbard Brian,Johnston Jennifer M.,Kavana Michael,Lisnock Jean-Marie,Liang Rui,Lu Jun,Lu Zhijian,Meng Juncai,Orth Peter,Palyha Oksana,Parthasarathy Gopal,Salowe Scott P.,Sharma Sujata,Shipman Jennifer,Soisson Stephen M.,Strack Alison M.,Youm Hyewon,Zhao Kake,Zink Deborah L.,Zokian Hratch,Addona George H.,Akinsanya Karen,Tata James R.,Xiong Yusheng,Imbriglio Jason E.

Funder

Merck & Co., Inc

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,Biochemistry

Reference40 articles.

1. Novel mutations of the PCSK9 gene cause variable phenotype of autosomal dominant hypercholesterolemia;Allard;Hum. Mutat.,2005

2. An affinity selection–mass spectrometry method for the identification of small molecule ligands from self-encoded combinatorial libraries: discovery of a novel antagonist of E. coli dihydrofolate reductase;Annis;Int. J. Mass Spectrom.,2004

3. Small-molecule inhibitors of protein-protein interactions: progressing toward the reality;Arkin;Chem. Biol.,2014

4. In situ click chemistry generation of cyclooxygenase-2 inhibitors;Bhardwaj;Nat. Commun.,2017

5. Kinetic target-guided synthesis in drug discovery and chemical biology: a comprehensive facts and figures survey;Bosc;Future Med. Chem.,2016

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3