Identification of RAD51–BRCA2 Inhibitors Using <i>N</i>-Acylhydrazone-Based Dynamic Combinatorial Chemistry-Reference-Cited by-同舟云学术

Identification of RAD51–BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry

Published:2022-07-28 Issue:8 Volume:13 Page:1262-1269
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Bagnolini Greta¹²³,Balboni Beatrice¹²,Schipani Fabrizio¹,Gioia Dario¹,Veronesi Marina⁴⁵,De Franco Francesca⁶,Kaya Cansu³⁷,Jumde Ravindra P.³,Ortega Jose Antonio¹,Girotto Stefania¹^ORCID,Hirsch Anna K. H.³⁷^ORCID,Roberti Marinella²^ORCID,Cavalli Andrea¹²^ORCID

Affiliation:

1. Computational & Chemical Biology (CCB), Istituto Italiano di Tecnologia (IIT), 16163 Genova, Italy

2. Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, 40126 Bologna, Italy

3. Helmholtz Centre for Infection Research (HZI), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), 66123 Saarbrücken, Germany

4. Structural Biophysics and Translational Pharmacology, Istituto Italiano di Tecnologia (IIT), 16163 Genova, Italy

5. D3-PharmaChemistry, Istituto Italiano di Tecnologia (IIT), 16163 Genova, Italy

6. TES Pharma Srl, I-06073 Corciano, Perugia Italy

7. Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany

Funder

Istituto Italiano di Tecnologia

Associazione Italiana per la Ricerca sul Cancro

Universit? di Bologna

Helmholtz Association

H2020 European Research Council

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.2c00063

Reference28 articles.

1. Use of the Rad51 promoter for targeted anti-cancer therapy

2. The consequences of Rad51 overexpression for normal and tumor cells

3. RAD-ical New Insights into RAD51 Regulation

4. Inhibiting homologous recombination by targeting RAD51 protein

5. Recent Developments Using Small Molecules to Target RAD51: How to Best Modulate RAD51 for Anticancer Therapy?

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