Identification of RAD51–BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry

Author:

Bagnolini Greta123,Balboni Beatrice12,Schipani Fabrizio1,Gioia Dario1,Veronesi Marina45,De Franco Francesca6,Kaya Cansu37,Jumde Ravindra P.3,Ortega Jose Antonio1,Girotto Stefania1ORCID,Hirsch Anna K. H.37ORCID,Roberti Marinella2ORCID,Cavalli Andrea12ORCID

Affiliation:

1. Computational & Chemical Biology (CCB), Istituto Italiano di Tecnologia (IIT), 16163 Genova, Italy

2. Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, 40126 Bologna, Italy

3. Helmholtz Centre for Infection Research (HZI), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), 66123 Saarbrücken, Germany

4. Structural Biophysics and Translational Pharmacology, Istituto Italiano di Tecnologia (IIT), 16163 Genova, Italy

5. D3-PharmaChemistry, Istituto Italiano di Tecnologia (IIT), 16163 Genova, Italy

6. TES Pharma Srl, I-06073 Corciano, Perugia Italy

7. Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany

Funder

Istituto Italiano di Tecnologia

Associazione Italiana per la Ricerca sul Cancro

Universit? di Bologna

Helmholtz Association

H2020 European Research Council

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

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