Recent Developments Using Small Molecules to Target RAD51: How to Best Modulate RAD51 for Anticancer Therapy?-Reference-Cited by-同舟云学术

Recent Developments Using Small Molecules to Target RAD51: How to Best Modulate RAD51 for Anticancer Therapy?

Published:2016-10-26 Issue:22 Volume:11 Page:2468-2473
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Budke Brian¹,Lv Wei²,Kozikowski Alan P.²,Connell Philip P.¹

Affiliation:

1. Department of Radiation and Cellular Oncology; University of Chicago; 5841 S. Maryland Ave. Chicago IL 60637 USA

2. Department of Medicinal Chemistry and Pharmacognosy; Drug Discovery Program; University of Illinois at Chicago; 833 S. Wood Street Chicago IL 60612 USA

Funder

US National Institutes of Health (NIH)

Wendy Will Cancer Fund

Stand Up To Cancer-Ovarian Cancer Research Fund-Ovarian Cancer National Alliance-National Ovarian Cancer Coalition Dream Team Translational Research Grant

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cmdc.201600426/fullpdf

Reference63 articles.

1. Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

2. XRCC2 and XRCC3, New Human Rad51-Family Members, Promote Chromosome Stability and Protect against DNA Cross-Links and Other Damages

3. Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene.

4. Targeting the homologous recombination pathway by small molecule modulators

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