Design and Synthesis of Novel, Selective GPR40 AgoPAMs-Reference-Cited by-同舟云学术

Design and Synthesis of Novel, Selective GPR40 AgoPAMs

Published:2017-01-30 Issue:2 Volume:8 Page:221-226
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Plummer Christopher W.¹^ORCID,Clements Matthew J.¹,Chen Helen¹,Rajagopalan Murali¹,Josien Hubert¹,Hagmann William K.¹,Miller Michael¹,Trujillo Maria E.¹,Kirkland Melissa¹,Kosinski Daniel¹,Mane Joel¹,Pachanski Michele¹,Cheewatrakoolpong Boonlert¹,Nolting Andrew F.¹,Orr Robert¹,Christensen Melodie¹,Campeau Louis-Charles¹,Wright Michael J.¹,Bugianesi Randal¹,Souza Sarah¹,Zhang Xiaoping¹,Di Salvo Jerry¹,Weinglass Adam B.¹,Tschirret-Guth Richard¹,Nargund Ravi¹,Howard Andrew D.¹,Colletti Steven L.¹

Affiliation:

1. Departments of †Discovery Chemistry, ‡Process Chemistry, §Drug Metabolism and Pharmacokinetics, ∥In Vivo Pharmacology, and ⊥In Vitro Pharmacology, Merck Research Laboratories, Kenilworth, New Jersey 07033, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.6b00443

Reference23 articles.

1. From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus

2. Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40

3. International Union of Pharmacology. LXXI. Free Fatty Acid Receptors FFA1, -2, and -3: Pharmacology and Pathophysiological Functions

4. Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist

5. Structure−Activity Study of Dihydrocinnamic Acids and Discovery of the Potent FFA1 (GPR40) Agonist TUG-469

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