Structure−Activity Study of Dihydrocinnamic Acids and Discovery of the Potent FFA1 (GPR40) Agonist TUG-469-Reference-Cited by-同舟云学术

Structure−Activity Study of Dihydrocinnamic Acids and Discovery of the Potent FFA1 (GPR40) Agonist TUG-469

Published:2010-07-02 Issue:7 Volume:1 Page:345-349
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Christiansen Elisabeth¹,Due-Hansen Maria E.¹,Urban Christian²,Merten Nicole³,Pfleiderer Michael⁴,Karlsen Kasper K.¹,Rasmussen Sanne S.¹,Steensgaard Mette¹,Hamacher Alexandra²,Schmidt Johannes³,Drewke Christel³,Petersen Rasmus Koefoed⁵,Kristiansen Karsten⁵,Ullrich Susanne⁴,Kostenis Evi³,Kassack Matthias U.²,Ulven Trond¹

Affiliation:

1. Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark

2. Pharmaceutical Biochemistry, Institute of Pharmaceutical and Medicinal Chemistry, University of Düsseldorf, Universitätsstrasse 1, D-40225 Düsseldorf, Germany

3. Department of Molecular, Cellular and Pharmacobiology Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, D-53115 Bonn, Germany

4. Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tübingen, Otfried-Müller-Strasse 10, D-72076 Tübingen, Germany

5. Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen N, Denmark

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml100106c

Reference30 articles.

1. International Diabetes Federation. The Diabetes Atlas,4th ed.; October, 2009; http://www.diabetesatlas.org.

2. The IDF Diabetes Atlas: Providing evidence, raising awareness and promoting action

3. The name FFA1 is designated by the International Union of Basic and Clinical Pharmacology to the receptor previously called GPR40 (http://www.iuphar.org/).

4. Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40

5. The Orphan G Protein-coupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids

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