Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities
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Published:2023-05
Issue:
Volume:85
Page:117273
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ISSN:0968-0896
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Container-title:Bioorganic & Medicinal Chemistry
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language:en
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Short-container-title:Bioorganic & Medicinal Chemistry
Author:
Jurica Elizabeth A.ORCID, Wu Ximao, Williams Kristin N., Haque Lauren E., Rampulla Richard A., Mathur ArvindORCID, Zhou Min, Cao Gary, Cai Hong, Wang Tao, Liu Heng, Xu Carrie, Kunselman Lori K., Antrilli Thomas M., Hicks Michael B., Sun Qin, Dierks Elizabeth A., Apedo Atsu, Moore Douglas B., Foster Kimberly A., Cvijic Mary Ellen, Panemangalore Reshma, Khandelwal Purnima, Wilkes Jason J., Zinker Bradley A., Robertson Donald G., Janovitz Evan B., Galella Michael, Li Yi-Xin, Li Julia, Ramar Thangeswaran, Jalagam Prasada Rao, Jayaram Ramya, Whaley Jean M.ORCID, Barrish Joel C.ORCID, Robl Jeffrey A., Ewing William R.ORCID, Ellsworth Bruce A.
Subject
Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry
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