Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs-Reference-Cited by-同舟云学术

Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs

Published:2016-06-13 Issue:8 Volume:7 Page:797-801
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Fader Lee D.¹,Bailey Murray¹,Beaulieu Eric¹,Bilodeau François¹,Bonneau Pierre¹,Bousquet Yves¹,Carson Rebekah J.¹,Chabot Catherine¹,Coulombe René¹,Duan Jianmin¹,Fenwick Craig¹,Garneau Michel¹,Halmos Ted¹,Jakalian Araz¹,James Clint¹,Kawai Stephen H.¹,Landry Serge¹,LaPlante Steven R.¹,Mason Stephen W.¹,Morin Sebastien¹,Rioux Nathalie¹,Simoneau Bruno¹,Surprenant Simon¹,Thavonekham Bounkham¹,Thibeault Carl¹,Trinh Thao¹,Tsantrizos Youla¹,Tsoung Jennifer¹,Yoakim Christiane¹,Wernic Dominik¹

Affiliation:

1. Research and Development, Boehringer Ingelheim (Canada) Ltd., 2100 Cunard Street, Laval, Québec H7S 2G5, Canada

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.6b00194

Reference8 articles.

1. Resistance against inhibitors of HIV-1 entry into target cells

2. Targeting HIV-1 integrase with strand transfer inhibitors

3. Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1