Discovery and Evaluation of C6-Substituted Pyrazolopyrimidine-Based Bisphosphonate Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase and Evaluation of Their Antitumor Efficacy in Multiple Myeloma, Pancreatic Ductal Adenocarcinoma, and Colorectal Cancer-Reference-Cited by-同舟云学术

Discovery and Evaluation of C6-Substituted Pyrazolopyrimidine-Based Bisphosphonate Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase and Evaluation of Their Antitumor Efficacy in Multiple Myeloma, Pancreatic Ductal Adenocarcinoma, and Colorectal Cancer

Published:2023-11-20 Issue:23 Volume:66 Page:15776-15800
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Boutin Rebecca¹,Lee Hiu-Fung¹,Guan Tian Lai¹²,Nguyen Tan Trieu³,Huang Xian Fang³,Waller Daniel D.⁴,Lu Jordan⁵,Christine Chio Iok In⁵⁶,Michel René P.⁷,Sebag Michael³⁸,Tsantrizos Youla S.¹²^ORCID

Affiliation:

1. Department of Chemistry, McGill University, Montreal, Québec H3A 0B8, Canada

2. Department of Biochemistry, McGill University, Montreal, Québec H3G 1Y6, Canada

3. Department of Medicine, McGill University, Montreal, Québec H3A 1A1, Canada

4. Terry Fox Laboratory, BC Cancer Research Institute, Vancouver, British Columbia V5Z 1L3, Canada

5. Institute for Cancer Genetics, Department of Genetics and Development, Columbia University Irving Medical Center, New York, New York 10032, United States

6. Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York 10032, United States

7. Department of Pathology, McGill University, Montréal, Québec H3A 1A1, Canada

8. Division of Hematology, McGill University Health Center, Montreal, Québec H4A 3J1, Canada

Funder

Canadian Institutes of Health Research

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01271

Reference89 articles.