Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore-Reference-Cited by-同舟云学术

Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore

Published:2022-02-21 Issue:5 Volume:65 Page:4270-4290
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tanaka Yuta¹^ORCID,Seto Masaki¹,Kakegawa Keiko¹,Takami Kazuaki¹,Kikuchi Fumiaki¹,Yamamoto Takeshi¹,Nakamura Minoru¹,Daini Masaki¹,Murakami Masataka¹,Ohashi Tomohiro¹,Kasahara Takahito¹,Wang Junsi¹,Ikeda Zenichi¹^ORCID,Wada Yasufumi¹,Puenner Florian¹,Fujii Takahiro¹,Inazuka Masakazu¹,Sato Sho¹,Suzaki Tomohiko¹,Oak Jeong-Ho¹,Takai Yuichi¹,Kohara Hiroshi¹,Kimoto Kouya¹^ORCID,Oki Hideyuki²,Mikami Satoshi¹^ORCID,Sasaki Minoru¹,Tanaka Yuta¹^ORCID

Affiliation:

1. Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan

2. Axcelead Drug Discovery Partners, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c02078

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1. Structures, Biosynthesis, and Functions of Gangliosides-an Overview

2. Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease