Phosphoramidate Prodrugs Continue to Deliver, The Journey of Remdesivir (GS-5734) from RSV to SARS-CoV-2
Author:
Affiliation:
1. Gilead Sciences, Inc., Foster City, California 94404 United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00624
Reference40 articles.
1. Prodrugs of a 1′-CN-4-Aza-7,9-dideazaadenosine C-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV
2. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses
3. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
4. Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
5. GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses
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