Overcoming the Pregnane X Receptor Liability: Rational Design to Eliminate PXR-Mediated CYP Induction
Author:
Affiliation:
1. GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00187
Reference32 articles.
1. Drug-Drug Interactions Among Elderly Patients Hospitalized for Drug Toxicity
2. Regulation of CYP3A Gene Transcription by the Pregnane X Receptor
3. Induction of Drug Metabolism: The Role of Nuclear Receptors
4. The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution
5. Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor
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