Dual Inhibition of TAF1 and BET Bromodomains from the BI-2536 Kinase Inhibitor Scaffold-Reference-Cited by-同舟云学术

Dual Inhibition of TAF1 and BET Bromodomains from the BI-2536 Kinase Inhibitor Scaffold

Published:2019-09-13 Issue:10 Volume:10 Page:1443-1449
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Remillard David¹^ORCID,Buckley Dennis L.²,Seo Hyuk-Soo¹^ORCID,Ferguson Fleur M.¹³^ORCID,Dhe-Paganon Sirano¹,Bradner James E.²,Gray Nathanael S.¹³^ORCID

Affiliation:

1. Department of Cancer Biology, Dana Farber Cancer Institute, Boston Massachusetts 02115, United States

2. Department of Medical Oncology, Dana Farber Cancer Institute, Boston Massachusetts 02115, United States

3. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston Massachusetts 02115, United States

Funder

Damon Runyon Cancer Research Foundation

Dana-Farber Cancer Institute

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00243

Reference43 articles.

1. Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

2. Selective inhibition of BET bromodomains

3. The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition

4. BET Bromodomain Proteins as Cancer Therapeutic Targets

5. Clinical progress and pharmacology of small molecule bromodomain inhibitors

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