Differential network analysis of ROS1 inhibitors reveals lorlatinib polypharmacology through co-targeting PYK2-Reference-Cited by-同舟云学术

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Differential network analysis of ROS1 inhibitors reveals lorlatinib polypharmacology through co-targeting PYK2

Published:2023-10 Issue: Volume: Page:
ISSN:2451-9456
Container-title:Cell Chemical Biology
language:en
Short-container-title:Cell Chemical Biology

Author:

Liao Yi,Remsing Rix Lily L.,Li Xueli,Fang Bin,Izumi Victoria,Welsh Eric A.,Monastyrskyi Andrii,Haura Eric B.,Koomen John M.,Doebele Robert C.,Rix Uwe^ORCID

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,Biochemistry

Reference55 articles.

1. Network pharmacology: the next paradigm in drug discovery;Hopkins;Nat. Chem. Biol.,2008

2. ROS1 rearrangements define a unique molecular class of lung cancers;Bergethon;J. Clin. Oncol.,2012

3. Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors;McDermott;Cancer Res.,2008

4. Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer;Lovly;Nat. Med.,2014

5. Turning liabilities into opportunities: Off-target based drug repurposing in cancer;Palve;Semin. Cancer Biol.,2021

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1. Cancer-associated fibroblasts confer ALK inhibitor resistance inEML4-ALK-driven lung cancer via concurrent integrin and MET signaling;2024-08-28

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