Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain-Reference-Cited by-同舟云学术

Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain

Published:2022-02-22 Issue:5 Volume:65 Page:4182-4200
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Karim Rezaul Md¹²^ORCID,Yang Leixiang³,Chen Lihong³,Bikowitz Melissa J.¹²^ORCID,Lu Junhao³,Grassie Dylan¹,Shultz Zachary P.¹,Lopchuk Justin M.¹^ORCID,Chen Jiandong³,Schönbrunn Ernst¹^ORCID

Affiliation:

1. Drug Discovery Department, Moffitt Cancer Center, Tampa, Florida 33612, United States

2. Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, United States

3. Department of Molecular Oncology, Moffitt Cancer Center, Tampa, Florida 33612, United States

Funder

Florida Department of Health

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01999

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