Mechanism-Based Design of 3-Amino-4-Halocyclopentenecarboxylic Acids as Inactivators of GABA Aminotransferase
Author:
Affiliation:
1. Department of Pharmacology, Northwestern University, Chicago, Illinois 60611, United States
Funder
National Institute on Drug Abuse
National Science Foundation
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00672
Reference27 articles.
1. Structure, evolution and action of vitamin B6-dependent enzymes
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3. Ornithine Aminotransferase versus GABA Aminotransferase: Implications for the Design of New Anticancer Drugs
4. Design and Mechanism of GABA Aminotransferase Inactivators. Treatments for Epilepsies and Addictions
5. The GABA Shunt: An Attractive and Potential Therapeutic Target in the Treatment of Epileptic Disorders
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