Development of a Platform To Enable Efficient Permeability Evaluation of Novel Organo-Peptide Macrocycles-Reference-Cited by-同舟云学术

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Development of a Platform To Enable Efficient Permeability Evaluation of Novel Organo-Peptide Macrocycles

Published:2019-05-09 Issue:6 Volume:10 Page:874-879
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Hopkins Brett A.¹^ORCID,Lee Hyelee¹^ORCID,Ha Sookhee²,Nogle Lisa¹,Sauvagnat Berengere³,McMinn Spencer¹,Smith Graham F.¹,Sciammetta Nunzio¹

Affiliation:

1. Discovery Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States

2. Computational, Structural Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

3. Pharmacology, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States

Funder

MRL Postdoctoral Research Fellows Program

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.9b00036

Reference16 articles.

1. The Discovery of Macrocyclic XIAP Antagonists from a DNA-Programmed Chemistry Library, and Their Optimization To Give Lead Compounds with in Vivo Antitumor Activity

2. Orally Active Peptides: Is There a Magic Bullet?

3. Peptide therapeutics: Targeting the undruggable space

4. Quantifying the chameleonic properties of macrocycles and other high-molecular-weight drugs

5. N-Methylation of Peptides: A New Perspective in Medicinal Chemistry

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1. Synthesis of Peptide Macrocycle via Metal‐Catalyzed CH Macrocyclization;Handbook of CH‐Functionalization;2022-10

2. Optimization of Cyclic Peptide Property Using Chromatographic Capacity Factor on Permeability of Passive Cell Membrane and Human Induced Pluripotent Stem Cell-Derived Intestinal Membrane;Journal of Pharmaceutical Sciences;2022-07

3. Parameter optimization of O2/He atmospheric pressure plasma for surface modification of poly (L-lactic) acid oriented fiber membranes: Improving cell adhesion and proliferation;Vacuum;2020-12

4. Structure–Permeability Relationship of Semipeptidic Macrocycles—Understanding and Optimizing Passive Permeability and Efflux Ratio;Journal of Medicinal Chemistry;2020-05-26

5. Updating the portfolio of physicochemical descriptors related to permeability in the beyond the rule of 5 chemical space;European Journal of Pharmaceutical Sciences;2020-04

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