Structure–Permeability Relationship of Semipeptidic Macrocycles—Understanding and Optimizing Passive Permeability and Efflux Ratio
Author:
Affiliation:
1. Department of Pharmacology-Physiology, Institut de Pharmacologie de Sherbrooke, 3001, 12e av nord, Sherbrooke, Québec J1H 5N4, Canada
2. Drug Discovery, Pharmaceuticals, Bayer AG, Wuppertal D-42096, Germany
Funder
Bayer
Canada Foundation for Innovation
Natural Sciences and Engineering Research Council of Canada
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00013
Reference51 articles.
1. The exploration of macrocycles for drug discovery — an underexploited structural class
2. Macrocycles Are Great Cycles: Applications, Opportunities, and Challenges of Synthetic Macrocycles in Drug Discovery
3. Macrocyclic Drugs and Clinical Candidates: What Can Medicinal Chemists Learn from Their Properties?
4. Practical Medicinal Chemistry with Macrocycles
5. Macrocycles in Drug Discovery
Cited by 23 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Macrocycles and macrocyclization in anticancer drug discovery: Important pieces of the puzzle;European Journal of Medicinal Chemistry;2024-03
2. Insights on Structure–Passive Permeability Relationship in Pyrrole and Furan-Containing Macrocycles;Journal of Medicinal Chemistry;2024-02-28
3. The backbone constitution drives passive permeability independent of side chains in depsipeptide and peptide macrocycles inspired by ent-verticilide;Chemical Science;2024
4. Addressing Challenges of Macrocyclic Conformational Sampling in Polar and Apolar Solvents: Lessons for Chameleonicity;Journal of Chemical Information and Modeling;2023-11-09
5. Beyond Rule-of-five: Permeability Assessment of Semipeptidic Macrocycles;Biochimica et Biophysica Acta (BBA) - Biomembranes;2023-10
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3