Escaping from Flatland: Substituted Bridged Pyrrolidine Fragments with Inherent Three-Dimensional Character-Reference-Cited by-同舟云学术

Escaping from Flatland: Substituted Bridged Pyrrolidine Fragments with Inherent Three-Dimensional Character

Published:2020-03-27 Issue:6 Volume:11 Page:1185-1190
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Cox Brian¹²^ORCID,Zdorichenko Victor²,Cox Philip B.³,Booker-Milburn Kevin I.⁴⁵^ORCID,Paumier Romain²,Elliott Luke D.⁴,Robertson-Ralph Michael⁵,Bloomfield Graham¹

Affiliation:

1. School of Life Sciences, University of Sussex, Brighton BN1 9QJ, U.K.

2. Photodiversity Ltd, c/o School of Life Sciences, University of Sussex, Brighton BN1 9QJ, U.K.

3. Drug Discovery Science and Technology, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064-6217, United States

4. School of Chemistry, University of Bristol, Cantock’s Close, Bristol BS8 1TS, U.K.

5. Photodiversity Ltd, c/o School of Chemistry, University of Bristol, Cantock’s Close, Bristol BS8 1TS, U.K.

Funder

Engineering and Physical Sciences Research Council

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00039

Reference15 articles.

1. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

2. What Do Medicinal Chemists Actually Make? A 50-Year Retrospective

3. Escape from Flatland 2: complexity and promiscuity

4. Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles

5. Escaping from Flatland: [2 + 2] Photocycloaddition; Conformationally Constrained sp3-rich Scaffolds for Lead Generation

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