Catalytic Asymmetric Construction of Chiral Polysubstituted 3-Azabicyclo[3.1.1]heptanes by Copper-Catalyzed Stereoselective Formal [4π+2σ] Cycloaddition-Reference-Cited by-同舟云学术

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Catalytic Asymmetric Construction of Chiral Polysubstituted 3-Azabicyclo[3.1.1]heptanes by Copper-Catalyzed Stereoselective Formal [4π+2σ] Cycloaddition

Published:2024-07-16 Issue:30 Volume:146 Page:21069-21077
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Wang Xunhua¹,Gao Rongkai¹,Li Xiaoxun¹²^ORCID

Affiliation:

1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China

2. Suzhou Institute of Shandong University, NO.388 Ruoshui Road, SIP, Suzhou, Jiangsu 215123, China

Funder

Natural Science Foundation of Jiangsu Province

Fundamental Research Fund of Shandong University

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.4c06436

Reference60 articles.

1. Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

2. Route to three-dimensional fragments using diversity-oriented synthesis

3. Two‐ and Three‐dimensional Rings in Drugs

4. Opportunities for Tapping into Three-Dimensional Chemical Space through a Quaternary Carbon

5. Evaluation of 3-Dimensionality in Approved and Experimental Drug Space

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