Discovery of Orally Active and Nonsteroidal Farnesoid X Receptor (FXR) Antagonist with Propensity for Accumulation and Responsiveness in Ileum-Reference-Cited by-同舟云学术

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Discovery of Orally Active and Nonsteroidal Farnesoid X Receptor (FXR) Antagonist with Propensity for Accumulation and Responsiveness in Ileum

Published:2021-02-24 Issue:3 Volume:12 Page:420-425
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Teno Naoki^ORCID,Iguchi Yusuke,Oda Keisuke,Yamashita Yukiko,Masuda Arisa,Fujimori Ko¹^ORCID,Une Mizuho,Gohda Keigo²

Affiliation:

1. Department of Pathobiochemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan

2. Computer-Aided Molecular Modeling Research Center, Kansai (CAMM-Kansai), 3-32-302, Tsuto-Otsuka, Nishinomiya 663-8241, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00640

Reference39 articles.

1. Identification of a Nuclear Receptor for Bile Acids

2. Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

3. A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis

4. Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR

5. CAR and PXR: The xenobiotic-sensing receptors☆

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1. FXR Antagonist FLG249 Lowers Hepatic Triacylglycerol and Serum Cholesterol Level in High-Fat Diet-Induced Obese Mice;Biological and Pharmaceutical Bulletin;2024-08-13

2. Tailoring FXR Modulators for Intestinal Specificity: Recent Progress and Insights;Molecules;2024-04-27

3. Discovery of 4-aminophenylacetamide derivatives as intestine-specific farnesoid X receptor antagonists for the potential treatment of nonalcoholic steatohepatitis;European Journal of Medicinal Chemistry;2024-01

4. Room-Temperature CuI-Catalyzed N-Arylation of Cyclopropylamine;The Journal of Organic Chemistry;2023-12-18

5. Discovery of FXR/PPARγ dual partial agonist;Bioorganic & Medicinal Chemistry;2023-05

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