FXR Antagonist FLG249 Lowers Hepatic Triacylglycerol and Serum Cholesterol Level in High-Fat Diet-Induced Obese Mice-Reference-Cited by-同舟云学术

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FXR Antagonist FLG249 Lowers Hepatic Triacylglycerol and Serum Cholesterol Level in High-Fat Diet-Induced Obese Mice

Published:2024-08-13 Issue:8 Volume:47 Page:1429-1436
ISSN:0918-6158
Container-title:Biological and Pharmaceutical Bulletin
language:en
Short-container-title:Biological & Pharmaceutical Bulletin

Author:

Iguchi Yusuke¹,Yamashita Yukiko¹,Gohda Keigo²,Oda Keisuke¹,Fujimori Ko³,Sera Yukihiro¹,Imanaka Tsuneo¹,Yamaguchi Masafumi¹⁴,Une Mizuho¹⁴,Teno Naoki⁴⁵

Affiliation:

1. Faculty of Pharmaceutical Sciences, Hiroshima International University

2. Computer-Aided Molecular Modeling Research Center, Kansai (CAMM-Kansai)

3. Department of Pathobiochemistry, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University

4. Graduate School of Pharmaceutical Sciences, Hiroshima International University

5. Faculty of Clinical Nutrition, Hiroshima International University

Publisher

Pharmaceutical Society of Japan

Link

https://www.jstage.jst.go.jp/article/bpb/47/8/47_b24-00311/_pdf

Reference35 articles.

1. 1) Li T, Chiang JY. Bile acid signaling in metabolic disease and drug therapy. Pharmacol. Rev., 66, 948–983 (2014).

2. 2) Watanabe M, Horai Y, Houten SM, Morimoto K, Sugizaki T, Arita E, Mataki C, Sato H, Tanigawara Y, Schoonjans K, Itoh H, Auwerx J. Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure. J. Biol. Chem., 286, 26913–26920 (2011).

3. 3) Jiang L, Zhang H, Xiao D, Wei H, Chen Y. Farnesoid X receptor (FXR): structures and ligands. Comput. Struct. Biotechnol. J., 19, 2148–2159 (2021).

4. 4) Wang K, Zhang Y, Wang G, Hao H, Wang H. FXR agonists for MASH therapy: lessons and perspectives from obeticholic acid. Med. Res. Rev., 44, 568–586 (2024).

5. 5) Katafuchi T, Makishima M. Molecular basis of bile acid-FXR-FGF15/19 signaling axis. Int. J. Mol. Sci., 23, 6046 (2022).

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