Discovery of FXR/PPARγ dual partial agonist-Reference-Cited by-同舟云学术

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Discovery of FXR/PPARγ dual partial agonist

Published:2023-05 Issue: Volume:85 Page:117238
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Yamashita Yukiko,Gohda Keigo,Iguchi Yusuke,Fujimori Ko,Oda Keisuke,Masuda Arisa,Une Mizuho,Teno Naoki

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference53 articles.

1. Identification of a nuclear receptor for bile acids;Makishima;Science,1999

2. Bile acids: Natural ligands for an orphan nuclear receptor;Parks;Science,1999

3. Role of FXR in liver inflammation during nonalcoholic steatohepatitis;Armstrong;Curr Pharmacol Rep.,2017

4. Farnesoid X receptor is essential for normal glucose homeostasis;Ma;J Clin Invest.,2006

5. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis;Sinal;Cell,2000

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1. FXR Antagonist FLG249 Lowers Hepatic Triacylglycerol and Serum Cholesterol Level in High-Fat Diet-Induced Obese Mice;Biological and Pharmaceutical Bulletin;2024-08-13

2. The gut-liver axis: emerging mechanisms and therapeutic approaches for nonalcoholic fatty liver disease and type 2 diabetes mellitus;Naunyn-Schmiedeberg's Archives of Pharmacology;2024-06-11

3. Roles and Mechanisms of Choline Metabolism in Nonalcoholic Fatty Liver Disease and Cancers;Frontiers in Bioscience-Landmark;2024-05-11

4. Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets;Signal Transduction and Targeted Therapy;2024-04-26

5. Development of bile acid activated receptors hybrid molecules for the treatment of inflammatory and metabolic disorders;Biochemical Pharmacology;2023-10

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