Novel Tricyclic Pyroglutamide Derivatives as Potent RORγt Inverse Agonists Identified using a Virtual Screening Approach-Reference-Cited by-同舟云学术

Novel Tricyclic Pyroglutamide Derivatives as Potent RORγt Inverse Agonists Identified using a Virtual Screening Approach

Published:2020-11-06 Issue:12 Volume:11 Page:2510-2518
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Liu Qingjie¹^ORCID,Batt Douglas G.¹,Weigelt Carolyn A.¹,Yip Shiuhang¹,Wu Dauh-Rurng¹,Ruzanov Max¹,Sack John S.¹,Wang Jinhong¹,Yarde Melissa¹,Li Sha¹,Shuster David J.¹,Xie Jenny H.¹,Sherry Tara¹,Obermeier Mary T.¹,Fura Aberra¹,Stefanski Kevin¹,Cornelius Georgia¹,Khandelwal Purnima¹,Tino Joseph A.¹,Macor John E.¹,Salter-Cid Luisa¹,Denton Rex¹,Zhao Qihong¹,Dhar T. G. Murali¹^ORCID

Affiliation:

1. Research and Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08540-4000, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00496

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2. The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

3. IL-17 and Th17 Cells