Affiliation:
1. Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou, Jiangsu 221116, PR China
Abstract
An N-heterocyclic carbene catalyzed radical tandem cyclization reaction of N-allylbromodifluoroacetamides and aldehydes has been developed. This method provides a protocol for synthesizing α,α-difluoro-γ-lactam derivatives in moderate to good results (27 examples, up to 88% yield, 10 : 1 d.r.).
Funder
National Natural Science Foundation of China
Natural Science Foundation of Jiangsu Province
Priority Academic Program Development of Jiangsu Higher Education Institutions
Jiangsu Normal University
Publisher
Royal Society of Chemistry (RSC)