Discovery, Synthesis, and In Vitro Characterization of 2,3 Derivatives of 4,5,6,7-Tetrahydro-Benzothiophene as Potent Modulators of Retinoic Acid Receptor-Related Orphan Receptor γt-Reference-Cited by-同舟云学术

Discovery, Synthesis, and In Vitro Characterization of 2,3 Derivatives of 4,5,6,7-Tetrahydro-Benzothiophene as Potent Modulators of Retinoic Acid Receptor-Related Orphan Receptor γt

Published:2023-05-12 Issue:11 Volume:66 Page:7355-7373
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Fouda Ahmed¹²^ORCID,Negi Sarita²,Zaremba Oleg³,Gaidar Rita S.⁴,Moroz Yurii S.⁴⁵^ORCID,Rusanov Eduard⁶⁷,Paraskevas Steven¹²⁸⁹,Tchervenkov Jean¹²⁸⁹

Affiliation:

1. Department of Experimental Surgery, McGill University, Montréal, Québec H3G 1A4, Canada

2. Research Institute of the McGill University Health Centre, Montréal, Québec H3H 2R9, Canada

3. Enamine Ltd, Kyïv 02660, Ukraine

4. Chemspace LLC, Kyïv 02094, Ukraine

5. Taras Shevchenko National University of Kyïv, Kyïv 01601, Ukraine

6. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Kyïv 02094, Ukraine

7. Department of Chemistry and Applied Biosciences, ETH Zürich, Zürich CH-8093, Switzerland

8. Department of Surgery, McGill University, Montréal, Québec H3G 1A4, Canada

9. McGill University Health Centre, Montréal, Québec H4A 3J1, Canada

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00021

Reference66 articles.

1. Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

2. ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer

3. Antagonizing Retinoic Acid-Related-Orphan Receptor Gamma Activity Blocks the T Helper 17/Interleukin-17 Pathway Leading to Attenuated Pro-inflammatory Human Keratinocyte and Skin Responses

4. Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin

5. A High RORγT/CD3 Ratio is a Strong Prognostic Factor for Postoperative Survival in Advanced Colorectal Cancer: Analysis of Helper T Cell Lymphocytes (Th1, Th2, Th17 and Regulatory T Cells)

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