Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation-Reference-Cited by-同舟云学术

Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation

Published:2020-09-29 Issue:11 Volume:11 Page:2268-2276
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Saraswati A. Prasanth¹,Relitti Nicola¹^ORCID,Brindisi Margherita¹^ORCID,Osko Jeremy D.²,Chemi Giulia¹^ORCID,Federico Stefano¹,Grillo Alessandro¹,Brogi Simone³^ORCID,McCabe Niamh H.⁴,Turkington Richard C.⁴,Ibrahim Ola⁵,O’Sullivan Jeffrey⁵,Lamponi Stefania¹,Ghanim Magda⁶,Kelly Vincent P.⁶,Zisterer Daniela⁶,Amet Rebecca⁶,Hannon Barroeta Patricia⁶,Vanni Francesca⁷,Ulivieri Cristina⁷,Herp Daniel⁸,Sarno Federica⁹,Di Costanzo Antonella⁹,Saccoccia Fulvio¹⁰,Ruberti Giovina¹⁰^ORCID,Jung Manfred⁸^ORCID,Altucci Lucia⁹,Gemma Sandra¹^ORCID,Butini Stefania¹^ORCID,Christianson David W.²^ORCID,Campiani Giuseppe¹^ORCID

Affiliation:

1. Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, I-53100 Siena, Italy

2. Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States

3. Department of Pharmacy, University of Pisa, via Bonanno 6, 56126, Pisa, Italy

4. Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, U.K.

5. School of Dental Science, Trinity College Dublin, Lincoln Place, Dublin 2, Ireland

6. School of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College, 152-160, Pearse Street, Dublin 2, Ireland

7. Department of Life Sciences, University of Siena, via Aldo Moro 2, I-53100 Siena, Italy

8. Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104, Freiburg, Germany

9. Department of Precision Medicine, University of Campania “Luigi Vanvitelli″, 80138 Naples, Italy

10. Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), via E. Ramarini 32, 00015 Monterotondo, Rome, Italy

Funder

H2020 Marie Sklodowska-Curie Actions

European Cooperation in Science and Technology

Office of Science

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00395

Reference26 articles.

1. Nuclear histone acetylases and deacetylases and transcriptional regulation: HATs off to HDACs

2. Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases

3. Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies

4. Screening and Phenotypical Characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) Inhibitors as Multistage Antischistosomal Agents

5. iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome

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