Targeting Relevant HDACs to Support the Survival of Cone Photoreceptors in Inherited Retinal Diseases: Identification of a Potent Pharmacological Tool with In Vitro and In Vivo Efficacy-Reference-Cited by-同舟云学术

Targeting Relevant HDACs to Support the Survival of Cone Photoreceptors in Inherited Retinal Diseases: Identification of a Potent Pharmacological Tool with In Vitro and In Vivo Efficacy

Published:2024-07-04 Issue:17 Volume:67 Page:14946-14973
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Carullo Gabriele¹^ORCID,Orsini Noemi²³,Piano Ilaria⁴,Pozzetti Luca¹^ORCID,Papa Alessandro¹,Fontana Anna¹,Napoli Debora²³,Corsi Francesca⁴,Marco Beatrice Di²³,Galante Alessia⁴,Marotta Ludovica¹,Panzeca Giovanna¹^ORCID,O’Brien Justine⁵,Sanchez Alicia Gomez⁵,Doherty Harry⁵,Mahon Niamh⁵,Clarke Leni⁵,Contri Chiara⁶,Pasquini Silvia⁷,Gorelli Beatrice⁸,Saponara Simona⁸,Valoti Massimo⁸,Vincenzi Fabrizio⁷,Varani Katia⁷,Ramunno Anna⁹^ORCID,Brogi Simone⁴^ORCID,Butini Stefania¹^ORCID,Gemma Sandra¹^ORCID,Kennedy Breandán N.⁵^ORCID,Gargini Claudia⁴,Strettoi Enrica²,Campiani Giuseppe¹¹⁰^ORCID

Affiliation:

1. Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy

2. Neuroscience Institute, Italian National Research Council (CNR) Area della Ricerca, Via Giuseppe Moruzzi 1, 56124 Pisa, Italy

3. Regional Doctorate School in Neuroscience of Universities of Florence, Pisa, Siena, Florence, CNR Via Giuseppe Moruzzi 1, 56124 Pisa, Italy

4. Department of Pharmacy, Via Bonanno 6, 56124 Pisa, Italy

5. UCD School of Biomolecular and Biomedical Science and UCD Conway Institute, University College Dublin, D04 V1W8 Dublin, Ireland

6. Department of Translational Medicine, University of Ferrara, Via Fossato di Mortara 17−19, 44121 Ferrara, Italy

7. Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Fossato di Mortara 17−19, 44121 Ferrara, Italy

8. Department of Life Sciences, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy

9. Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84100 Fisciano (SA), Italy

10. Bioinformatics Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan 81746-7346, Iran

Funder

Ministero dell'Universit? e della Ricerca

Velux Stiftung

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00477

Reference59 articles.

1. Retinal degeneration: molecular mechanisms and therapeutic strategies

2. Cone photoreceptor dysfunction in retinitis pigmentosa revealed by optoretinography

3. Retinal Pigment Epithelium Remodeling in Mouse Models of Retinitis Pigmentosa

4. Mechanism of Cone Degeneration in Retinitis Pigmentosa

5. Retinitis Pigmentosa: Progress in Molecular Pathology and Biotherapeutical Strategies