Enabling Deoxygenative C(sp<sup>2</sup>)-C(sp<sup>3</sup>) Cross-Coupling for Parallel Medicinal Chemistry-Reference-Cited by-同舟云学术

Enabling Deoxygenative C(sp²)-C(sp³) Cross-Coupling for Parallel Medicinal Chemistry

Published:2023-05-22 Issue:6 Volume:14 Page:853-859
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Liu Wei¹,Mulhearn James¹^ORCID,Hao Bo¹,Cañellas Santiago²^ORCID,Last Stefaan³,Gómez José Enrique²^ORCID,Jones Alexander³^ORCID,De Vera Alexander¹,Kumar Kiran¹^ORCID,Rodríguez Raquel²,Van Eynde Lars³,Strambeanu Iulia I.¹,Wolkenberg Scott E.¹^ORCID

Affiliation:

1. Discovery Chemistry, Janssen Research & Development LLC, 1400 McKean Road, Spring House, Pennsylvania 19477, United States

2. Discovery Chemistry, Janssen Research & Development LLC, Janssen-Cilag, S.A., E-45007 Toledo, Spain

3. Discovery Chemistry, Janssen Research & Development LLC, 2340 Beerse, Belgium

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00118

Reference40 articles.

1. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

2. Bioisosteres of the Phenyl Ring: Recent Strategic Applications in Lead Optimization and Drug Design

3. Improvement in Aqueous Solubility in Small Molecule Drug Discovery Programs by Disruption of Molecular Planarity and Symmetry

4. Fsp3: A new parameter for drug-likeness

5. The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

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